In cell scalaradial interactome profiling using a bio-orthogonal clickable probe.
نویسندگان
چکیده
A bio-orthogonal click-chemistry procedure was developed to allow the in cell interactome profiling of scalaradial, an anti-inflammatory marine natural product. The results were validated through the application of the classical in vitro chemical proteomics and several bio-physical methods; peroxiredoxins, 14-3-3 isoforms and proteasomes were recognized as main scalaradial targets.
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ورودعنوان ژورنال:
- Chemical communications
دوره 50 45 شماره
صفحات -
تاریخ انتشار 2014